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27 Apr2021

SQZ Biotechnologies to Present New Data on Rapid Cell Therapy Manufacturing Capabilities and Advantages in Cell Performance at ASGCT 2021

Written by 2020HCP.com. Posted in News

WATERTOWN, Mass.–(BUSINESS WIRE)– SQZ Biotechnologies (NYSE: SQZ), a cell therapy company developing novel treatments for multiple therapeutic areas, announced today that it will present new data on the company’s scaled cGMP cell therapy manufacturing program at the 2021 American Society for Gene and Cell Therapy Virtual Annual Meeting (ASGCT) from May 11-14. The company will also present findings on the performance advantages of cells engineered through its proprietary Cell Squeeze® Technology.

“There is tremendous therapeutic need for faster and more efficient delivery of impactful cell therapies to patients around the world,” said Armon Sharei, PhD, Chief Executive Officer at SQZ Biotechnologies. “Through our manufacturing and therapeutic development programs, we strive to transform the current cell therapy paradigm and are excited to share our progress at ASGCT.”

Rapid, Scaled cGMP and Aseptic Manufacturing Program Data

Company scientists will present new data on its proprietary Cell Squeeze® manufacturing technology demonstrating its ability to rapidly and reproducibly deliver cell therapy doses at scale. The presentation will show that the company’s cGMP and aseptic manufacturing program can process 10 billion cells per minute with greater than 90 percent cell viability. The company is delivering its first investigational drug (SQZ-PBMC-HPV) utilizing this core technology for its Phase 1 clinical trial in patients with Human Papillomavirus positive (HPV+) tumors.

“The company’s cell therapy manufacturing program has proven in our Phase 1 trial its ability to deliver reproducible investigational drug batches rapidly and at scale,” said Howard Bernstein, MD, PhD, Chief Scientific Officer at SQZ Biotechnologies. “Our advances in cell therapy manufacturing will potentially enable multiple therapeutics across oncology, infectious disease, and immune disorders to be developed and delivered to a broad patient population.”

Cell Performance Advantages

Additionally, in a poster presentation, company scientists assessed the use of Cell Squeeze® technology to deliver pre-complexed CRISPR/Cas9 RNPs to achieve multiplex-edited primary human T cells. When comparing the functional effects of the Cell Squeeze® technology to the commonly used electroporation approach, the authors found significant differences in transcriptional changes between the two treatments. Cells treated with electroporation corresponded with aberrant cytokine production, potentially resulting in premature T cell exhaustion. SQZ™ treated T cells, however, did not have disrupted transcriptional profiles or cytokine production and readily expanded post treatment with robustness similar to untreated cells.

“This work highlights the advantages of using the Cell Squeeze® technology for cell engineering,” said Jonathan Gilbert, PhD, Vice President of Exploratory Research at SQZ Biotechnologies. “We demonstrate preclinically a clear distinction in cell performance with the ability to achieve multiple, distinct gene edits with more viable and functional cells.”

ASGCT Presentation Titles and Timing

SQZ cGMP Manufacturing Presentation
Title
:Effective and Efficient Intracellular Delivery Achieved with the Cell Squeeze® Technology Enables Rapid, Scaled, and Reproducible Production of Cell Therapies
Presenter: David Chirgwin
Session Title: Advances in Ex Vivo Modified Cell Therapies
Abstract Number: 4
Date & Time: Tuesday, May 11 from 6:15 – 6:30 PM EST

SQZ Multiplexed Gene Editing Poster
Title
:Advantages of the Cell Squeeze® Technology for Multiplex Gene Editing
Presenter: 
Jacquelyn Hanson, PhD
Session Title: Cell Therapies
Abstract Number: 769
Date & Time: Tuesday, May 11 from 8:00 – 10:00 AM EST

About SQZ Biotechnologies

SQZ Biotechnologies is a clinical-stage biotechnology company developing transformative cell therapies for patients with cancer, infectious diseases, and other serious conditions. Using its proprietary technology, SQZ Biotechnologies offers the unique ability to deliver multiple materials into many patient cell types to engineer what we believe can be an unprecedented range of potential therapeutics for a variety of diseases. SQZ Biotechnologies has the potential to create well-tolerated cell therapies that can provide therapeutic benefit for patients and to improve the patient experience over existing cell therapy approaches. With accelerated production timelines under 24 hours and the opportunity to eliminate preconditioning and lengthy hospital stays, our goal is to use the SQZ™ approach to establish a new paradigm for cell therapies. Our first therapeutic applications aim to leverage the potential to generate target-specific immune responses, both in activation for the treatment of solid tumors and immune tolerance for the treatment of unwanted immune reactions and autoimmune diseases. For more information, please visit www.sqzbiotech.com.

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